|
KMID : 0369819830130010047
|
|
Jorunal of Korean Pharmaceutical Sciences
1983 Volume.13 No. 1 p.47 ~ p.47
|
|
|
The 12th Annual Academic Convention ; A Study on the Relative Bioavailability of Doxycycline Hyclate and Doxycycline - L methylenelysine
|
|
김종갑/Kim JK
최영욱/Choi YW
|
|
|
Abstract
|
|
|
|
The present study was undertaken to evaluate the relative bioavailability of doxycycline hyclate and doxycycline-L methylenelysine, a new synthetic derivative of doxycycline. Single doses, equivalent to 100㎎ of doxycycline hyclate, were administered orally to 10 healthy male volunteers. Serum concentrations were determined periodically over 12 hrs by microbiological assay. Peak serum concentrations were reached within 4 hrs: doxycycline hyclate (1.38mcg·㎖^(-1)) gave 1.66 times higher concentration than that of doxycycline-L methylenelysine (0.83mcg·㎖^(-1)). And the areas under the serum concentration-time curves 0 to 12 hrs were 8.38mcg·hr·㎖^(-1) (doxycycline hyclate) and 5.56mcg·hr·㎖^(-1)(doxycycline-L methylenelysine).
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|